Star polymers for gene delivery
نویسندگان
چکیده
منابع مشابه
Amylose-Based Cationic Star Polymers for siRNA Delivery
A new siRNA delivery system using a cationic glyco-star polymer is described. Spermine-modified 8-arm amylose star polymer (with a degree of polymerization of approximately 60 per arm) was synthesized by chemoenzymatic methods. The cationic star polymer effectively bound to siRNA and formed spherical complexes with an average hydrodynamic diameter of 230 nm. The cationic 8-arm star polymer comp...
متن کاملCationic lipids and polymers for gene delivery
Gene therapy, aiming to eradicate causes rather than symptoms of diseases, is believed to be the therapy of the future. A new promising area for the application of gene therapy is the emerging field of regenerative medicine, where gene delivery can be used to enhance or modify cell functions in an organ/tissue or in engineered substitutes. The aim of gene therapy is to achieve the expression of...
متن کاملReducible, Dibromomaleimide-linked Polymers for Gene Delivery.
Polycations have been successfully used as gene transfer vehicles both in vitro and in vivo; however, their cytotoxicity has been associated with increasing molecular weight. Polymers that can be rapidly degraded after internalization are typically better tolerated by mammalian cells compared to their non-degradable counterparts. Here, we report the use of a dibromomaleimide-alkyne (DBM-alkyne)...
متن کاملEngineering biodegradable and multifunctional peptide-based polymers for gene delivery
The complex nature of in vivo gene transfer establishes the need for multifunctional delivery vectors capable of meeting these challenges. An additional consideration for clinical translation of synthetic delivery formulations is reproducibility and scale-up of materials. In this review, we summarize our work over the last five years in developing a modular approach for synthesizing peptide-bas...
متن کاملStar Polymers: An Overview
This review article describes the synthesis, properties and some applications of star-shaped polymers. The arms constituted of homoor co-polymers of different polymers are also reviewed. Methods of synthesis of various types of starshaped polymers, including “arm first” and “core first” procedures, is given as an introduction along with some details. Then, the synthesis of star polymers (includ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Polymer International
سال: 2014
ISSN: 0959-8103
DOI: 10.1002/pi.4718